Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08MHD
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| Former ID |
DIB002510
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| Drug Name |
E-2609
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| Synonyms |
Beta secretase inhibitor (Alzheimer's disease), Eisai
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 3 | [1], [2] | |
| Company |
Eisai Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H18F3N5O2S
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| Canonical SMILES |
CC1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(N=C4)C(F)F)F)N
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| InChI |
1S/C19H18F3N5O2S/c1-9-12-7-30-18(23)27-19(12,8-29-9)11-4-10(2-3-13(11)20)26-17(28)15-6-24-14(5-25-15)16(21)22/h2-6,9,12,16H,7-8H2,1H3,(H2,23,27)(H,26,28)/t9-,12-,19-/m1/s1
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| InChIKey |
AACUJFVOHGRMTR-DPXNYUHVSA-N
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| CAS Number |
CAS 1388651-30-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-secretase (BACE) | Target Info | Inhibitor | [3] |
| Beta-secretase 1 (BACE1) | Target Info | Inhibitor | [1], [2] | |
| KEGG Pathway | Alzheimer disease | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014 March; 13(3): 319-329. | |||
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