Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08LZZ
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| Former ID |
DIB016350
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| Drug Name |
DPO-1
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| Synonyms |
IKur blockers (atrial arrythmia), Merck & Co; Kv1.5 voltage-gated potassium channel antagonists (atrial arrythmia); Kv1.5 voltage-gated potassium channel antagonists (atrial arrythmia), Merck & Co
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| Drug Type |
Small molecular drug
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| Indication | Atrial fibrillation [ICD-11: BC81.3; ICD-10: I48] | Investigative | [1] | |
| Company |
Merck & Co Inc
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| Structure |
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Download2D MOL |
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| Formula |
C22H29OP
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| Canonical SMILES |
CC1CCC(C(C1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C(C)C
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| InChI |
1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1
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| InChIKey |
BPCNGVCAHAIZEE-COPCDDAFSA-N
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| CAS Number |
CAS 43077-30-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93748
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv1.5 (KCNA5) | Target Info | Antagonist | [1] |
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| WikiPathways | Potassium Channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 542). | |||
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