Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08LFC
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| Former ID |
DNC014555
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| Drug Name |
CGP-35024
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| Synonyms |
3-Aminopropyl(methyl)phosphinic Acid; 3-Apmpa; 3-aminopropyl(methyl)phosphinic Acid; skf-97541; 127729-35-5; F 97541; CGP 35024; SKF 97541; (3-(Aminopropyl)methyl)phosphinic acid; CHEMBL112710; SKF 97541 hydrochloride; CGP35024; SKF-97,541; (3-aminopropyl)(methyl)phosphinic acid; Phosphinic acid, (3-(aminopropyl)methyl)-; (3-ammoniopropyl)methylphosphinate; SR-01000076225; (3-aminopropyl)methylphosphinic acid; Tocris-0379; Phosphinic acid, (3-aminopropyl)methyl-; Lopac-A-196; AC1L1JVX; Biomol-NT_000257; AC1Q6RJ4; Lopac0_000098; C4H12NO2P; SKF-97541
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H12NO2P
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| Canonical SMILES |
CP(=O)(CCCN)O
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| InChI |
1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)
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| InChIKey |
NHVRIDDXGZPJTJ-UHFFFAOYSA-N
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| CAS Number |
CAS 127729-35-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5608484, 7978903, 8153213, 11110690, 11113473, 15219048, 25746534, 26751694, 29224286, 47216900, 47365331, 47662433, 47885537, 48185114, 50064309, 50104385, 53786182, 57322666, 77292575, 85208918, 90513940, 103065080, 103080796, 103334994, 104308634, 117626404, 117733988, 124749445, 124879060, 124879061, 124879062, 124879063, 125660989, 128704542, 131751337, 134224389, 134351760, 135081534, 135649731, 137008675, 140384422, 162223784, 164848763, 166270618, 179148822, 179419315, 204360310, 224018692, 226677152, 241181641
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Inhibitor | [1], [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am J Physiol. 1999 Oct;277(4 Pt 1):G867-74. | |||
| REF 2 | Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993). | |||
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