Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08KXE
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| Former ID |
DIB005856
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| Drug Name |
RP-67580
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| Synonyms |
RP-68651
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Terminated | [1], [2] | |
| Company |
Rhone-Poulenc SA
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| Structure |
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Download2D MOL |
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| Formula |
C29H30N2O2
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| Canonical SMILES |
COC1=CC=CC=C1CC(=N)N2CC3C(C2)C(CCC3=O)(C4=CC=CC=C4)C5=CC=CC=C5
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| InChI |
1S/C29H30N2O2/c1-33-27-15-9-8-10-21(27)18-28(30)31-19-24-25(20-31)29(17-16-26(24)32,22-11-4-2-5-12-22)23-13-6-3-7-14-23/h2-15,24-25,30H,16-20H2,1H3/t24-,25+/m0/s1
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| InChIKey |
VWBOQFANCXZMAU-LOSJGSFVSA-N
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| CAS Number |
CAS 135911-02-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980540, 10234385, 11114161, 14783557, 14881367, 40868218, 44436660, 47434827, 48329033, 49985780, 53790404, 57338184, 78924432, 91746412, 103363389, 103938905, 104379486, 129535460, 135062674, 135698314, 142259802, 144240326, 163123906, 164759127, 176224062, 178100502, 184538686, 198990164, 204360674, 215780419, 223554806, 224943912, 230286750, 241033092, 241182590, 252321394
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Substance-P receptor (TACR1) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Measles | ||||
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Spinal Cord Injury | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3522). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001969) | |||
| REF 3 | Effects of RP 67580, a tachykinin NK1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord. Br J Pharmacol. 1994 Dec;113(4):1141-6. | |||
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