Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08GTH
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| Former ID |
DNC008581
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| Drug Name |
WFwLL-NH2
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| Synonyms |
CHEMBL450217; wFwLL-NH2; BDBM50260269
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C43H54N8O5
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| Canonical SMILES |
CC(C)CC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CNC5=CC=CC=C54)N
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| InChI |
1S/C43H54N8O5/c1-25(2)18-35(39(45)52)48-41(54)36(19-26(3)4)50-43(56)38(22-29-24-47-34-17-11-9-15-31(29)34)51-42(55)37(20-27-12-6-5-7-13-27)49-40(53)32(44)21-28-23-46-33-16-10-8-14-30(28)33/h5-17,23-26,32,35-38,46-47H,18-22,44H2,1-4H3,(H2,45,52)(H,48,54)(H,49,53)(H,50,56)(H,51,55)/t32-,35+,36+,37+,38-/m1/s1
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| InChIKey |
YFSSMBIPKDBQSL-CLZHSDMDSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. | |||
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