Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08EJQ
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| Former ID |
DNC013590
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| Drug Name |
1-hydroxy-3-(4-(trifluoromethyl)phenyl)urea
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| Synonyms |
CHEMBL260172; SCHEMBL12491371
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H7F3N2O2
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| Canonical SMILES |
C1=CC(=CC=C1C(F)(F)F)NC(=O)NO
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| InChI |
1S/C8H7F3N2O2/c9-8(10,11)5-1-3-6(4-2-5)12-7(14)13-15/h1-4,15H,(H2,12,13,14)
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| InChIKey |
DRFSQRMYIQLAMQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosinase (TYR) | Target Info | Inhibitor | [1] |
| BioCyc | (S)-reticuline biosynthesis | |||
| Eumelanin biosynthesis | ||||
| L-dopachrome biosynthesis | ||||
| KEGG Pathway | Tyrosine metabolism | |||
| Riboflavin metabolism | ||||
| Metabolic pathways | ||||
| Melanogenesis | ||||
| Pathwhiz Pathway | Riboflavin Metabolism | |||
| Tyrosine Metabolism | ||||
| WikiPathways | Dopamine metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. | |||
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