Drug Information
Drug General Information | Top | |||
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Drug ID |
D08DOG
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Former ID |
DNC008970
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Drug Name |
A-846714
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Synonyms |
JMC516547 Compound 2; A-846714; 2-Aminopyrimidine analog., 4; SCHEMBL2166660; CHEMBL494678; BDBM26229
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H18N6
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Canonical SMILES |
CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=C(C=C3)C#N)N
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InChI |
1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)
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InChIKey |
QFKQUMBUFVKQBH-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histamine H4 receptor (H4R) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCR ligand binding | |||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and... J Med Chem. 2008 Oct 23;51(20):6547-57. |
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