Drug Information
Drug General Information | Top | |||
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Drug ID |
D07ZMG
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Drug Name |
Thiazole carboxamide derivative 29
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Synonyms |
PMID25684022-Compound-WO2012036974 24(45)
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Indication | Metastatic cancer [ICD-11: 2D50-2E2Z] | Patented | [1] | |
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
Company |
MERCK SHARP & DOHME CORP. TSUI, Hon-Chung PALIWAL, Sunil FISCHMANN, Thierry Olivier
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Structure |
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Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target Info | Inhibitor | [1] |
Target's Patent Info | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target's Patent Info | [1] | |
KEGG Pathway | HIF-1 signaling pathway | |||
Axon guidance | ||||
Central carbon metabolism in cancer |
References | Top | |||
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REF 1 | PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. |
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