Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07TMR
|
|||
| Former ID |
DNC001687
|
|||
| Drug Name |
ISIS 23722
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1] | |
| Company |
Isis Pharmaceuticals
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Apoptosis inhibitor survivin (BIRC5) | Target Info | Modulator | [2] |
| KEGG Pathway | Hippo signaling pathway | |||
| Hepatitis B | ||||
| Pathways in cancer | ||||
| Colorectal cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| Pathway Interaction Database | Aurora B signaling | |||
| Validated targets of C-MYC transcriptional activation | ||||
| FOXM1 transcription factor network | ||||
| Aurora A signaling | ||||
| Reactome | Separation of Sister Chromatids | |||
| Resolution of Sister Chromatid Cohesion | ||||
| RHO GTPases Activate Formins | ||||
| Mitotic Prometaphase | ||||
| WikiPathways | IL-4 Signaling Pathway | |||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Mitotic Metaphase and Anaphase | ||||
| Mitotic Prometaphase | ||||
| Apoptosis | ||||
| Interleukin-11 Signaling Pathway | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01630733) A Multinational, Randomized, Open-Label Study of Custirsen In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.Eur J Cancer.2012 Mar;48(5):763-71. | |||
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