Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07SCN
|
|||
| Former ID |
DIB004168
|
|||
| Drug Name |
KC-11458
|
|||
| Indication | Gastric motility disorder [ICD-11: DA21; ICD-10: K22.4] | Discontinued in Phase 2 | [1] | |
| Company |
Solvay SA
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Motilin receptor (MLNR) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008138) | |||
| REF 2 | Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8. | |||
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