Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07QJK
|
|||
| Former ID |
DNCL002075
|
|||
| Drug Name |
Plitidepsin
|
|||
| Synonyms |
Aplidin (TN)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Phase 3 | [1] | |
| Angioimmunoblastic T-cell Lymphoma [ICD-11: 2A90.9; ICD-10: C86.5; ICD-9: 2A90.9] | Phase 2 | [2] | ||
| Company |
PharmaMar
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C57H87N7O15
|
|||
| Canonical SMILES |
CCC(C)C1C(CC(=O)OC(C(=O)C(C(=O)NC(C(=O)N2CCCC2C(=O)N(C(C(=O)OC(C(C(=O)N1)NC(=O)C(CC(C)C)N(C)C(=O)C3CCCN3C(=O)C(=O)C)C)CC4=CC=C(C=C4)OC)C)CC(C)C)C)C(C)C)O
|
|||
| InChI |
1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1
|
|||
| InChIKey |
UUSZLLQJYRSZIS-LXNNNBEUSA-N
|
|||
| CAS Number |
CAS 137219-37-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:90205
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Palmitoyl-protein thioesterase 1 (PPT1) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.