Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07PXQ
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| Former ID |
DIB016592
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| Drug Name |
ASP-2151
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| Synonyms |
Helicase-primase inhibitor (herpes infection), Astellas
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| Drug Type |
Small molecular drug
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| Indication | Herpes simplex virus infection [ICD-11: 1F00; ICD-10: B00; ICD-9: 54] | Phase 3 | [1] | |
| Company |
Astellas Pharma Inc
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| Structure |
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Download2D MOL |
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| Formula |
C24H26N4O5S
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| Canonical SMILES |
CC1=C(C(=CC=C1)C)N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CCS(=O)(=O)CC4
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| InChI |
1S/C24H26N4O5S/c1-16-4-3-5-17(2)22(16)28(24(30)19-10-12-34(31,32)13-11-19)14-21(29)26-20-8-6-18(7-9-20)23-25-15-33-27-23/h3-9,15,19H,10-14H2,1-2H3,(H,26,29)
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| InChIKey |
MNHNIVNAFBSLLX-UHFFFAOYSA-N
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| CAS Number |
CAS 841301-32-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus Helicase-primase (HSV UL8) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025919) | |||
| REF 2 | Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo. Antiviral Res. 2012 Feb;93(2):301-4. | |||
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