Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07PTH
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| Former ID |
DIB012605
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| Drug Name |
13-cis-retinoic acid
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| Synonyms |
CRA, UCSD
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| Indication | Glioma [ICD-11: 2A00.0; ICD-9: 191] | Phase 3 | [1] | |
| Azoospermia [ICD-11: GB04.0] | Phase 2 | [2] | ||
| Infertility [ICD-11: GB04; ICD-10: N46] | Phase 2 | [2] | ||
| Company |
University of California San Diego
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor (RAR) | Target Info | Modulator | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74. | |||
| REF 2 | ClinicalTrials.gov (NCT03323801) RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia. U.S. National Institutes of Health. | |||
| REF 3 | 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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