Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07OAC
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| Former ID |
DNC000702
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| Drug Name |
GP515
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| Synonyms |
1H-Pyrazolo(3,4-d)pyrimidin-4-amine, 1-(5-amino-5-deoxy-beta-D-ribofuranosyl)-3-bromo-; GP 1-515; CHEMBL356141; 144928-48-3; GP-515; Adenosine kinase inhibitor GP515; GP-1-515; SCHEMBL2053010; AC1L31E2; DTXSID30162847; BDBM50134744; 1-(5-Amino-5-deoxy-beta-D-ribofuranosyl)-3-bromo-1H-pyrazolo(3,4-d)pyrimidin-4-amine; 4-Amino-1-(5-amino-5-deoxy-1-beta-D-ribofuranosyl)-3-bromopyrazolo(3,4-d)pyrimidine; (2R,3R,4S,5R)-2-(4-amino-3-bromopyrazolo[3,4-d]pyrimidin-1-yl)-5-(aminomethyl)oxolane-3,4-diol; 19-nor-10-azasteroid skeleton
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H13BrN6O3
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| Canonical SMILES |
C1=NC(=C2C(=N1)N(N=C2Br)C3C(C(C(O3)CN)O)O)N
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| InChI |
1S/C10H13BrN6O3/c11-7-4-8(13)14-2-15-9(4)17(16-7)10-6(19)5(18)3(1-12)20-10/h2-3,5-6,10,18-19H,1,12H2,(H2,13,14,15)/t3-,5-,6-,10-/m1/s1
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| InChIKey |
LTTBFVDMHCIDPM-BHBWVORQSA-N
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| CAS Number |
CAS 144928-48-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine kinase (ADK) | Target Info | Inhibitor | [2] |
| Steroid 5-alpha-reductase 1 (SRD5A1) | Target Info | Inhibitor | [1] | |
| Steroid 5-alpha-reductase 2 (SRD5A2) | Target Info | Inhibitor | [1] | |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Allopregnanolone biosynthesis | ||||
| Androgen biosynthesis | ||||
| Superpathway of purine nucleotide salvage | ||||
| Adenine and adenosine salvage II | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Prostate cancer | ||||
| Purine metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Reactome | Androgen biosynthesis | |||
| Purine salvage | ||||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. | |||
| REF 2 | Adenosine kinase inhibitor GP515 improves experimental colitis in mice. J Pharmacol Exp Ther. 2001 Jan;296(1):99-105. | |||
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