Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07NTC
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| Former ID |
DIB011509
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| Drug Name |
WCK-771
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| Synonyms |
WCK-771A
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Phase 2 | [1] | |
| Company |
Wockhardt Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H35FN6O6
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| Canonical SMILES |
CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O.C(CC(C(=O)O)N)CN=C(N)N
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| InChI |
1S/C19H21FN2O4.C6H14N4O2/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21;7-4(5(11)12)2-1-3-10-6(8)9/h8-11,23H,2-7H2,1H3,(H,25,26);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t10-;4-/m00/s1
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| InChIKey |
WIFOPRFVQIVWTB-YBVIJTQESA-N
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| CAS Number |
CAS 306748-89-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial DNA gyrase (Bact gyrase) | Target Info | Modulator | [2], [3] |
| Staphylococcus Topoisomerase IV (Stap-coc parC) | Target Info | Modulator | [2], [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016734) | |||
| REF 2 | Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models | |||
| REF 3 | The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA gyrase.Antimicrob Agents Chemother.2006 Nov;50(11):3568-79. | |||
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