Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07NAH
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| Former ID |
DNC005744
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| Drug Name |
5-Naphthalen-2-yl-1H-imidazole
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| Synonyms |
SCHEMBL2369049; BDBM8931; CHEMBL370822; 5-(2-Naphthyl)-1H-imidazole; 4-(2-Naphthyl)-1H-imidazole; BDBM220125; 5-(naphthalen-2-yl)-1h-imidazole; Imidazole-substituted naphthalene 27; ZINC13674488; US9271963, 27
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H10N2
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| Canonical SMILES |
C1=CC=C2C=C(C=CC2=C1)C3=CN=CN3
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| InChI |
1S/C13H10N2/c1-2-4-11-7-12(6-5-10(11)3-1)13-8-14-9-15-13/h1-9H,(H,14,15)
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| InChIKey |
CTUKWPHHWRYGEH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid 11-beta-hydroxylase (CYP11B1) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Mineralocorticoid biosynthesis | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Steroidogenesis | |||
| Reactome | Glucocorticoid biosynthesis | |||
| Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | |||
| Oxidation by Cytochrome P450 | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. | |||
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