Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07MME
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| Former ID |
DIB012296
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| Drug Name |
Dexamethasone palmitate
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| Synonyms |
Cortiject; Dexamethasone palmitate, Novagali; NOVA-22026; NOVA-22032; NOVA-63035; Corticosteroid therapy (ophthalmic emulsion, Novasorb), Novagali; Retinopathy therapy (ophthalmic emulsion, Novasorb), Novagali
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| Drug Type |
Small molecular drug
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| Indication | Choroidal neovascularization [ICD-11: 9B76; ICD-10: H44.2] | Phase 1/2 | [1] | |
| Company |
Santen
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| Structure |
 |
Download2D MOL |
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| Formula |
C38H59FO6
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| Canonical SMILES |
CCCCCCCCCCCCCCCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)O
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| InChI |
1S/C38H59FO6/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-34(43)45-26-33(42)38(44)27(2)23-31-30-20-19-28-24-29(40)21-22-35(28,3)37(30,39)32(41)25-36(31,38)4/h21-22,24,27,30-32,41,44H,5-20,23,25-26H2,1-4H3/t27-,30+,31+,32+,35+,36+,37+,38+/m1/s1
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| InChIKey |
WDPYZTKOEFDTCU-WDJQFAPHSA-N
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| CAS Number |
CAS 14899-36-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:31471
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Agonist | [2] |
| Reactome | PPARA activates gene expression | |||
| Transcriptional activation of mitochondrial biogenesis | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mitochondrial Gene Expression | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Santen Pharmaceutical. | |||
| REF 2 | Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet. 2002 Jul 20;360(9328):211-8. | |||
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