Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07IZG
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| Former ID |
DIB019959
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| Drug Name |
GSK4112
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| Synonyms |
SR6452; GSK-4112
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| Drug Type |
Small molecular drug
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C18H21ClN2O4S
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| Canonical SMILES |
CC(C)(C)OC(=O)CN(CC1=CC=C(C=C1)Cl)CC2=CC=C(S2)[N+](=O)[O-]
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| InChI |
1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
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| InChIKey |
WYSLOKHVFKLWOU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | V-erbA-related protein 1 (NR1D1) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6(2):131-4. | |||
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