Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07IEM
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| Former ID |
DCL000045
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| Drug Name |
AMG-8562
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| Synonyms |
UNII-X2S52Z1DY9; X2S52Z1DY9; AMG-8562; AMG 8562; 1041478-78-7; SCHEMBL14993014; SCHEMBL14993018; 2-Propenamide, N-((2R)-2,3-dihydro-2-hydroxy-1H-inden-4-yl)-3-(2-(1-piperidinyl)-4-(trifluoromethyl)phenyl)-, (2E)-; (r,e)-n-(2-hydroxy-2,3-dihydro-1h-inden-4-yl)-3-(2-(piperidin-1-yl)-4 (trifluoromethyl)phenyl)acrylamide
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Terminated | [1] | |
| Therapeutic Class |
Analgesics
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| Company |
Amgen
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H25F3N2O2
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| Canonical SMILES |
C1CCN(CC1)C2=C(C=CC(=C2)C(F)(F)F)C=CC(=O)NC3=CC=CC4=C3CC(C4)O
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| InChI |
1S/C24H25F3N2O2/c25-24(26,27)18-9-7-16(22(14-18)29-11-2-1-3-12-29)8-10-23(31)28-21-6-4-5-17-13-19(30)15-20(17)21/h4-10,14,19,30H,1-3,11-13,15H2,(H,28,31)/b10-8+/t19-/m1/s1
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| InChIKey |
HAZYXDWNLMGLIS-LHUXKHBRSA-N
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| CAS Number |
CAS 1041478-78-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020509) | |||
| REF 2 | Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. | |||
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