Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07HLS
|
|||
| Former ID |
DCL000048
|
|||
| Drug Name |
Anacetrapib
|
|||
| Synonyms |
MK0859; Anacetrapib (USAN); MK-0859
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Arteriosclerosis [ICD-11: BD40; ICD-10: I70] | Phase 3 | [1], [2] | |
| Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 2 | [1], [2] | ||
| Company |
Merck
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C30H25F10NO3
|
|||
| Canonical SMILES |
CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
|
|||
| InChI |
1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1
|
|||
| InChIKey |
MZZLGJHLQGUVPN-HAWMADMCSA-N
|
|||
| CAS Number |
CAS 875446-37-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
16658560, 23677163, 42698323, 57376836, 77084272, 96025538, 125240981, 125299337, 126671698, 126731193, 134338754, 134449322, 135252031, 135723595, 135727855, 136340336, 136354914, 136367491, 136368100, 136988957, 137140669, 140430199, 144115606, 152258394, 152344255, 160647231, 162011426, 162038221, 162205119, 164023422, 164194107, 164835813, 164835814, 170499297, 174007279, 174531057, 198963790, 198991968, 203355967, 205994811, 223381545, 223435184, 223683902, 223704791, 224000756, 226842677, 242591118, 242786119, 249736586, 249821974
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesteryl ester transfer protein (CETP) | Target Info | Inhibitor | [3], [4], [5] |
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | LDL-mediated lipid transport | |||
| HDL-mediated lipid transport | ||||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8400). | |||
| REF 2 | Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. | |||
| REF 3 | Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (C... Br J Clin Pharmacol. 2009 May;67(5):520-6. | |||
| REF 4 | Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):183-227. | |||
| REF 5 | The end of the road for CETP inhibitors after torcetrapib Curr Opin Cardiol. 2009 Jul;24(4):364-71. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.