Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07FSW
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| Former ID |
DNC000110
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| Drug Name |
8-hydroxyguanine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H5N5O2
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| Canonical SMILES |
C12=C(NC(=O)N1)N=C(NC2=O)N
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| InChI |
1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
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| InChIKey |
CLGFIVUFZRGQRP-UHFFFAOYSA-N
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| CAS Number |
CAS 5614-64-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
84843, 3135546, 4919642, 6311397, 6544738, 8189550, 14769547, 14818416, 22395071, 26753825, 32454889, 43121991, 49749828, 50068032, 51072119, 53790256, 57315354, 58689355, 76591018, 81058842, 96022321, 104333031, 118306573, 118520281, 119524940, 123059939, 125607996, 126524307, 127641595, 132504690, 134223896, 135023124, 135824301, 135935257, 136001735, 137008330, 137088829, 137137984, 142354401, 142562192, 143306708, 143431404, 143526144, 145468784, 160826234, 162232895, 162876233, 163128990, 163311900, 163840978
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| ChEBI ID |
CHEBI:52617
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GTP cyclohydrolase-I (GCH1) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Pterine Biosynthesis | |||
| Reactome | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73. | |||
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