Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07FIY
|
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| Drug Name |
PMID25666693-Compound-50
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
| Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
| Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
| Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
| Company |
GRUENENTHAL GMBH [DE]
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C21H21ClF3N5O2
|
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| Canonical SMILES |
CC(C1=CN=C(C=C1)NCCO)C(=O)NCC2=CC(=NN2C3=CC(=CC=C3)Cl)C(F)(F)F
|
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| InChI |
1S/C21H21ClF3N5O2/c1-13(14-5-6-19(27-11-14)26-7-8-31)20(32)28-12-17-10-18(21(23,24)25)29-30(17)16-4-2-3-15(22)9-16/h2-6,9-11,13,31H,7-8,12H2,1H3,(H,26,27)(H,28,32)
|
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| InChIKey |
QZMPZIHZYACLIU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. | |||
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