Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07EJY
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| Former ID |
DIB006043
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| Drug Name |
AR-12286
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| Synonyms |
AR-11236; AR-12080; AR-12132; CF-286-03; CF-286-04
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| Indication | Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Phase 2 | [1] | |
| Company |
Aerie Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C17H17N3O2S
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| Canonical SMILES |
CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3
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| InChI |
1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22)
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| InChIKey |
VDYRZXYYQMMFJW-UHFFFAOYSA-N
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| CAS Number |
CAS 1414854-42-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Rho-associated protein kinase (ROCK) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01699464) A Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-12286 in Patients With Elevated Intraocular Pressure for 3 Months. U.S. National Institutes of Health. | |||
| REF 2 | Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1. | |||
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