Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07DUU
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| Former ID |
DAP001289
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| Drug Name |
Alglucosidase alfa
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| Synonyms |
Lumizyme (TN); Myozyme (TN)
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| Indication | Pompe disease [ICD-11: 5C51.3; ICD-10: E74; ICD-9: 271] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Enzyme Replacement Agents
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| Company |
Genzyme Corporation
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| ADReCS Drug ID | BADD_D00071 | |||
| SuperDrug ATC ID |
A16AB07
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mannose-6-phosphate receptor (M6PR) | Target Info | Binder | [4] |
| KEGG Pathway | Lysosome | |||
| Phagosome | ||||
| Reactome | Lysosome Vesicle Biogenesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7561). | |||
| REF 2 | 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. | |||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 125141. | |||
| REF 4 | Early treatment with alglucosidase alpha prolongs long-term survival of infants with Pompe disease. Pediatr Res. 2009 Sep;66(3):329-35. | |||
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