Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07CLY
|
|||
| Drug Name |
Heterocycle-containing compound 3
|
|||
| Synonyms |
PMID25828189-Compound-15
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
PFIZER INC. ASPNES, Gary, Erik DIDIUK, Mary, Theresa FILIPSKI, Kevin, James GUZMAN-PEREZ, Angel PFEFFERKORN, Jeffrey, Allen STEVENS, Benjamin, Dawson TU, Meihua, Mik
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C27H29F3N4O3
|
|||
| Canonical SMILES |
CC1=CC(=CN=C1C2=CC=C(C=C2)C(F)(F)F)NC(CC(C)C)C3=NC=C(C=C3)C(=O)NCCC(=O)O
|
|||
| InChI |
1S/C27H29F3N4O3/c1-16(2)12-23(22-9-6-19(14-32-22)26(37)31-11-10-24(35)36)34-21-13-17(3)25(33-15-21)18-4-7-20(8-5-18)27(28,29)30/h4-9,13-16,23,34H,10-12H2,1-3H3,(H,31,37)(H,35,36)
|
|||
| InChIKey |
XWKCFFJMDVSXKD-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.