Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07BIF
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| Former ID |
DIB018257
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| Drug Name |
[3H]CGP27492
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| Synonyms |
3-Aminopropylphosphinic acid; 3-aminopropylphosphinic acid; 3-Aminopropanephosphinic acid; CGP-27492; Cgp 27492; 3-Aminopropylphosphonous acid; Phosphinic acid, (3-aminopropyl); 3-aminopropyl-hydroxy-oxophosphanium; CHEMBL112203; [3H]3-APPA; [3H]-3-APPA; Cgp 27 492; [3H]-CGP27492; AC1O3S7O; SCHEMBL341549; GTPL5381; GTPL1081; BDBM24184; CTK8G4752; (3-Amino-propyl)-phosphinic acid; ZTHNRNOOZGJLRR-UHFFFAOYSA-N; MolPort-019-939-257; CGP27492; 3-aminopropyl-hydroxy-oxo-phosphonium; BN0804; PDSP2_001468; PDSP1_001484; FCH933647; 3-aminopropylphosphinic; [3H]-CGP27492
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C3H9NO2P+
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| Canonical SMILES |
C(CN)C[P+](=O)O
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| InChI |
1S/C3H8NO2P/c4-2-1-3-7(5)6/h1-4H2/p+1
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| InChIKey |
MQIWYGZSHIXQIU-UHFFFAOYSA-O
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| CAS Number |
CAS 103680-47-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [3] |
| Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Inhibitor | [4] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| cAMP signaling pathway | ||||
| Estrogen signaling pathway | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| Activation of G protein gated Potassium channels | ||||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5381). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1081). | |||
| REF 3 | Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. | |||
| REF 4 | Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993). | |||
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