Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07AMZ
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| Drug Name |
Spiroimidazolone derivative 5
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| Synonyms |
PMID25828189-Compound-32
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| Drug Type |
Small molecular drug
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| Company |
MERCK SHARP & DOHME CORP. DEMONG, Duane, E. MILLER, Michael, W. DAI, Xing WONG, Michael, K. LAVEY, Brian, J. YU, Wensheng ZHOU, Guowei STAMFORD, Andrew, W. KOZLOWSKI, Joseph, A. GREENLEE, William, J. ZHAO, He CHEN, Ping LIN, Peishan DAI, Peng DAVIS, Jason Louis
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| Structure |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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