Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06ZVB
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| Former ID |
DIB020082
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| Drug Name |
isobutyric acid
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| Synonyms |
isobutyrate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C4H8O2
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| Canonical SMILES |
CC(C)C(=O)O
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| InChI |
1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)
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| InChIKey |
KQNPFQTWMSNSAP-UHFFFAOYSA-N
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| CAS Number |
CAS 79-31-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5612, 109779, 589582, 822966, 831518, 3133571, 5571527, 7849762, 7885849, 7888473, 8144996, 8154239, 10536111, 15291552, 24870590, 24881084, 24895944, 24900936, 24900937, 29225550, 30172622, 30981496, 37340905, 37904330, 46392244, 46506341, 46507055, 48414828, 48416879, 49856729, 57323569, 76498013, 85087045, 85165228, 87571503, 88826169, 99374469, 102851917, 103327747, 103826851, 104312499, 104667156, 117366070, 117542897, 124955192, 125275595, 125326084, 125563338, 126524188, 126678141
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| ChEBI ID |
CHEBI:16135
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Free fatty acid receptor 2 (FFAR2) | Target Info | Agonist | [2] |
| Free fatty acid receptor 3 (FFAR3) | Target Info | Agonist | [3] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1060). | |||
| REF 2 | Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003 Jul 11;278(28):25481-9. | |||
| REF 3 | Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50. | |||
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