Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06YFT
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| Former ID |
DIB018509
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| Drug Name |
1-methyl-L-tryptophan
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| Synonyms |
1-L-MT; 1-LMT
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C12H14N2O2
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| Canonical SMILES |
CN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
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| InChI |
1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
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| InChIKey |
ZADWXFSZEAPBJS-JTQLQIEISA-N
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| CAS Number |
CAS 21339-55-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3138569, 9281121, 15068214, 24714968, 24868339, 44861306, 56424231, 57408519, 74441382, 92456839, 93166598, 99373846, 103579834, 104098852, 109857891, 118260437, 124557225, 129873352, 131305213, 134346667, 135055726, 136912400, 139137891, 143394395, 152165747, 152245670, 160824198, 162185385, 162244589, 162501137, 163386621, 172860411, 179325009, 201760157, 202539267, 202540570, 204430147, 223519681, 224515657, 226409605, 249565905, 249855538, 250202628, 252067475, 252134697, 252375444, 252417691
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [2] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31. | |||
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