Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06VNK
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| Former ID |
DAP000545
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| Drug Name |
Succinic acid
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| Synonyms |
Asuccin; Bernsteinsaeure; Bernsteinsaure; Butandisaeure; Katasuccin; SIN; Succ; Succinellite; Wormwood; Acid of amber; Acide butanedioique; Acide succinique; Acidum succinicum; Amber acid; Bernsteinsaure [German]; Butanedioic acid diammonium salt; Butanedionic acid; Dihydrofumaric acid; Ethanedicarboxylic acid; Ethylene dicarboxylic acid; Ethylene succinic acid; Ethylenesuccinic acid; Kyselina jantarova; Kyselina jantarova [Czech]; Potassium Succinate; Sal succini; Spirit of amber; Succinicum acidum; Succinicun acidum; Wormwood acid; A 12084; Butanedioic acid (9CI); SUCCINIC ACID, ACS; Succinate, 9; Succinic acid (8CI); Amber acid, Butanedioic acid, Ethylenesuccinic acid; 1,2-Ethanedicarboxylic acid; 1,4-BUTANEDIOIC ACID (SUCCINIC ACID); 1,4-Butanedioic acid
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| Drug Type |
Small molecular drug
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| Indication | Malnutrition [ICD-11: 5B50-5B71] | Approved | [1], [2] | |
| Therapeutic Class |
Dietary supplement
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| Structure |
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Download2D MOL |
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| Formula |
C4H6O4
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| Canonical SMILES |
C(CC(=O)O)C(=O)O
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| InChI |
1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
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| InChIKey |
KDYFGRWQOYBRFD-UHFFFAOYSA-N
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| CAS Number |
CAS 110-15-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3344, 86941, 406687, 584433, 584435, 584437, 584563, 584564, 587866, 607133, 819425, 819559, 819708, 820894, 821223, 821226, 821516, 821762, 824501, 824648, 826312, 829565, 831043, 834460, 836699, 836870, 837846, 837917, 838888, 841754, 3135967, 4403520, 6436447, 7890496, 8017187, 8017189, 8027919, 8138088, 8145138, 8150978, 10318445, 10503810, 10514060, 14710842, 15321249, 17403733, 17403764, 17422159, 17422181, 17424988
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| ChEBI ID |
CHEBI:15741
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| SuperDrug ATC ID |
P03AX03
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| SuperDrug CAS ID |
cas=000121755
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Succinate-semialdehyde dehydrogenase (ALDH5A1) | Target Info | Inhibitor | [3], [4], [5] |
| BioCyc | GABA shunt | |||
| 4-aminobutyrate degradation | ||||
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
| Butanoate metabolism | ||||
| Metabolic pathways | ||||
| Panther Pathway | Aminobutyrate degradation | |||
| Gamma-aminobutyric acid synthesis | ||||
| Pathwhiz Pathway | Glutamate Metabolism | |||
| WikiPathways | GABA synthesis, release, reuptake and degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3637). | |||
| REF 2 | Handbook of Food Analysis: Residues and other food component analysis. 2006, P914. By Leo M. L. Nollet. | |||
| REF 3 | Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. | |||
| REF 4 | Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. Mol Microbiol. 2006 Oct;62(1):45-56. | |||
| REF 5 | The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Curr Drug Metab. 2005 Apr;6(2):127-39. | |||
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