Drug Information
Drug General Information | Top | |||
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Drug ID |
D06TWA
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Drug Name |
TB-403
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Indication | Glioblastoma of brain [ICD-11: 2A00.00; ICD-10: C71] | Phase 2 | [1] | |
Company |
BioInvent International Lund, Sweden Oncurious Leuven, Belgium
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Placenta growth factor (PlGF) | Target Info | Inhibitor | [2] |
KEGG Pathway | Ras signaling pathway | |||
Rap1 signaling pathway | ||||
PI3K-Akt signaling pathway | ||||
Focal adhesion | ||||
Pathways in cancer | ||||
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | ||||
Metabolic pathways | ||||
NetPath Pathway | TSH Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | VEGFR1 specific signals | |||
Reactome | VEGF ligand-receptor interactions | |||
VEGF binds to VEGFR leading to receptor dimerization | ||||
WikiPathways | Focal Adhesion | |||
Signaling by VEGF | ||||
Diurnally Regulated Genes with Circadian Orthologs | ||||
Post-translational modification: synthesis of GPI-anchored proteins |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT01622764) 89Zr-RO5323441 PET Imaging in Glioblastoma. U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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