Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06QOF
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| Former ID |
DCL000612
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| Drug Name |
R7128
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| Synonyms |
R-4048; R-7128; RG-7128; RO-5024048
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Discontinued in Phase 2 | [1] | |
| Company |
Roche
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| Structure |
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Download2D MOL |
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| Formula |
C18H26FN3O6
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| Canonical SMILES |
CC(C)C(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)(C)F)OC(=O)C(C)C
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| InChI |
1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1
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| InChIKey |
MLESJYFEMSJZLZ-MAAOGQSESA-N
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| CAS Number |
CAS 940908-79-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025214) | |||
| REF 2 | Clinical pipeline report, company report or official report of Roche (2009). | |||
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