Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06QGJ
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| Former ID |
DNC011214
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| Drug Name |
3-(1-benzylpiperidin-4-yloxy)benzamide
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| Synonyms |
3-((1-Benzylpiperidin-4-yl)oxy)benzamide; 1254475-25-6; CHEMBL1257457; 3-[(1-Benzylpiperidin-4-yl)oxy]benzamide; 3-(1-benzylpiperidin-4-yloxy)benzamide; DTXSID90680658; ZINC64548741; BDBM50327259; AKOS022176132; AJ-114866
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H22N2O2
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| Canonical SMILES |
C1CN(CCC1OC2=CC=CC(=C2)C(=O)N)CC3=CC=CC=C3
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| InChI |
1S/C19H22N2O2/c20-19(22)16-7-4-8-18(13-16)23-17-9-11-21(12-10-17)14-15-5-2-1-3-6-15/h1-8,13,17H,9-12,14H2,(H2,20,22)
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| InChIKey |
IDSIUINGWBNUFD-UHFFFAOYSA-N
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| CAS Number |
CAS 1254475-25-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor kappa (OPRK1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Opioid prodynorphin pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
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| REF 1 | Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5847-52. | |||
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