Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06PZC
|
|||
| Former ID |
DIB011107
|
|||
| Drug Name |
SAM-6
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Melanoma [ICD-11: 2C30; ICD-9: 172] | Phase 1 | [1] | |
| Company |
Pack of Parker; OncoMab GmbH
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endoplasmic reticulum chaperone BiP (HSPA5) | Target Info | . | [2] |
| KEGG Pathway | Protein export | |||
| Protein processing in endoplasmic reticulum | ||||
| Antigen processing and presentation | ||||
| Thyroid hormone synthesis | ||||
| Prion diseases | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Parkinson disease | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Platelet degranulation | |||
| Regulation of HSF1-mediated heat shock response | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Activation of Chaperone Genes by ATF6-alpha | ||||
| Parkin-Ubiquitin Proteasomal System pathway | ||||
| Unfolded Protein Response | ||||
| Response to elevated platelet cytosolic Ca2+ | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01727778) Safety and Preliminary Efficacy Study of the Antibody PAT-SM6 in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health. | |||
| REF 2 | A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest. 2008 Apr;88(4):375-86. | |||
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