Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06PNU
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| Former ID |
DNC006335
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| Drug Name |
Tic-D-Phe-Arg-2-Nal-NHCH3
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| Synonyms |
CHEMBL381357; Tic-D-Phe-Arg-2-Nal-NHCH3
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C39H46N8O4
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| Canonical SMILES |
CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CC5=CC=CC=C5CN4
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| InChI |
1S/C39H46N8O4/c1-42-35(48)33(22-26-17-18-27-12-5-6-13-28(27)20-26)46-36(49)31(16-9-19-43-39(40)41)45-38(51)34(21-25-10-3-2-4-11-25)47-37(50)32-23-29-14-7-8-15-30(29)24-44-32/h2-8,10-15,17-18,20,31-34,44H,9,16,19,21-24H2,1H3,(H,42,48)(H,45,51)(H,46,49)(H,47,50)(H4,40,41,43)/t31-,32-,33-,34+/m0/s1
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| InChIKey |
MCHDZFRIUNRJGL-GZXHTMMISA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melanocortin receptor 1 (MC1R) | Target Info | Inhibitor | [1] |
| Melanocortin receptor 3 (MC3R) | Target Info | Inhibitor | [1] | |
| Melanocortin receptor 4 (MC4R) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Melanogenesis | ||||
| Pathway Interaction Database | Syndecan-3-mediated signaling events | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. | |||
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