Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06OVX
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| Former ID |
DIB018536
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| Drug Name |
25-hydroxycholesterol
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| Synonyms |
25-OHC
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C27H46O2
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| Canonical SMILES |
CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
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| InChI |
1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
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| InChIKey |
INBGSXNNRGWLJU-ZHHJOTBYSA-N
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| CAS Number |
CAS 2140-46-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
629188, 7850677, 7888091, 8025559, 8189506, 14781420, 17396511, 26697233, 43121934, 46506794, 49688257, 50125921, 53790556, 57288449, 57288687, 57315308, 57390573, 78391031, 81087183, 87550999, 89649910, 103428966, 104332860, 126691998, 128191611, 135022176, 135651392, 137026010, 144206343, 160967689, 162814985, 172829377, 179317056, 184573804, 198989052, 223664194, 223720460, 224144613, 226538331, 241043524, 249925282
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| ChEBI ID |
CHEBI:42977
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | EBV-induced G-protein coupled receptor 2 (GPR183) | Target Info | Agonist | [2] |
| Nuclear receptor ROR-gamma (RORG) | Target Info | Agonist | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2885). | |||
| REF 2 | Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. | |||
| REF 3 | Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9. | |||
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