Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NPB
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| Former ID |
DND000033
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| Drug Name |
GLPG-0259
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| Synonyms |
G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Discontinued in Phase 2 | [1] | |
| Company |
Johnson&Johnson
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| Structure |
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Download2D MOL |
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| Formula |
C24H26N8O2
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| Canonical SMILES |
CC(C)N1CC2CC1CN2C3=CC=C(C=C3)NC4=NC=C(N5C4=NC=N5)C6=COC(=C6)C(=O)N
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| InChI |
1S/C24H26N8O2/c1-14(2)30-10-19-8-18(30)11-31(19)17-5-3-16(4-6-17)29-23-24-27-13-28-32(24)20(9-26-23)15-7-21(22(25)33)34-12-15/h3-7,9,12-14,18-19H,8,10-11H2,1-2H3,(H2,25,33)(H,26,29)/t18-,19-/m0/s1
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| InChIKey |
YBFGSJUVEOYPIS-OALUTQOASA-N
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| CAS Number |
CAS 1195065-29-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | MAPK-activated protein kinase 5 (MAPKAPK5) | Target Info | Inhibitor | [2] |
| Pathway Interaction Database | Signaling mediated by p38-alpha and p38-beta | |||
| Reactome | Oxidative Stress Induced Senescence | |||
| MAPK6/MAPK4 signaling | ||||
| WikiPathways | p38 MAPK Signaling Pathway | |||
| MAPK Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Galapagos. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2096). | |||
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