Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06JMV
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| Former ID |
DNC012882
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| Drug Name |
PB-27
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| Synonyms |
PB-27; CHEMBL192244; BDBM13327; tetrahydroquinoline (THQ)-based inhibitor 4i
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H25N7O2S
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| Canonical SMILES |
CN1C=NC=C1CN2CC(CC3=C2C=CC(=C3)C#N)N(CC4=CC=CC=N4)S(=O)(=O)C5=CC=CC=N5
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| InChI |
1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
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| InChIKey |
GQLZRVHYGCXHSR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CAAX farnesyltransferase beta (FNTB) | Target Info | Inhibitor | [1] |
| Farnesyl protein transferase (Ftase) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Reactome | Inactivation, recovery and regulation of the phototransduction cascade | |||
| WikiPathways | Visual phototransduction | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. | |||
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