Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06JAL
|
|||
| Former ID |
DIB000476
|
|||
| Drug Name |
8H9
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Brain cancer [ICD-11: 2A00] | Phase 1 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [2] | ||
| Company |
Memorial Sloan-Kettering Cancer Center
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tenascin (TNC) | Target Info | . | [3] |
| KEGG Pathway | PI3K-Akt signaling pathway | |||
| Focal adhesion | ||||
| ECM-receptor interaction | ||||
| MicroRNAs in cancer | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | |||
| Beta3 integrin cell surface interactions | ||||
| Alpha9 beta1 integrin signaling events | ||||
| Syndecan-4-mediated signaling events | ||||
| Reactome | Integrin cell surface interactions | |||
| Syndecan interactions | ||||
| ECM proteoglycans | ||||
| WikiPathways | TGF beta Signaling Pathway | |||
| Focal Adhesion | ||||
| Syndecan interactions | ||||
| Extracellular matrix organization | ||||
| Integrin cell surface interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01502917) Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy. U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT01099644) Intraperitoneal Radioimmunotherapy With 131I-8H9 for Patients With Desmoplastic Small Round Cell Tumors and Other Solid Tumors Involving the Peritoneum. U.S. NationalInstitutes of Health. | |||
| REF 3 | In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 2004 Feb 15;64(4):1419-24. | |||
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