Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06GWF
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| Former ID |
DAP000646
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| Drug Name |
Valganciclovir
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| Synonyms |
Cymeval; RS 79070; RO1079070/194; Valcyte (TN); Valganciclovir (INN); Valganciclovir (Oral); Valganciclovir [INN:BAN]; L-Valine, ester with ganciclovir; [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate; L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester; 5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7-dihydro-3H-imidazo[4,5-d]pyrimidin-7-one
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiviral Agents
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| Company |
Roche Laboratories Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H22N6O5
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| Canonical SMILES |
CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N
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| InChI |
1S/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1
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| InChIKey |
WPVFJKSGQUFQAP-GKAPJAKFSA-N
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| CAS Number |
CAS 175865-60-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
615108, 7980872, 14852135, 14852136, 15916891, 16292870, 16867892, 43121054, 46505524, 47205808, 50064546, 50113281, 50647485, 57315041, 91616537, 92251598, 104330216, 117576840, 123099361, 126681567, 129616655, 134337936, 135022474, 135611114, 137260967, 141634799, 142044094, 152035502, 152105972, 160647806, 160964847, 162205159, 163621140, 164830911, 172086164, 178101427, 184546497, 184823771, 223661894, 226416180, 237715327, 251916051, 251917399
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| ChEBI ID |
CHEBI:63635
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| ADReCS Drug ID | BADD_D02326 ; BADD_D02327 | |||
| SuperDrug ATC ID |
J05AB14
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| SuperDrug CAS ID |
cas=175865608
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4716). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22. | |||
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