Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06GUA
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| Former ID |
DIB012220
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| Drug Name |
GSK2269557
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8] | Phase 2 | [1] | |
| Company |
Glaxosmithkline
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C26H28N6O
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| Canonical SMILES |
CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=C4C=NNC4=CC(=C3)C5=C6C=CNC6=CC=C5
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| InChI |
1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)
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| InChIKey |
MCIDWGZGWVSZMK-UHFFFAOYSA-N
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| CAS Number |
CAS 1254036-71-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Stress-activated protein kinase (p38) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02522299) A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Acute Exacerbation. | |||
| REF 2 | Evaluation of WO2012032067 and WO2012055846: two selective PI3Kdelta inhibitors, which is GSK-2269557. Expert Opin Ther Pat. 2012 Aug;22(8):965-70. | |||
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