Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06GGI
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| Drug Name |
Tricyclic isoxazoloquinazoline derivative 2
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| Synonyms |
PMID27646439-Compound-12
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| Drug Type |
Small molecular drug
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| Company |
NERVIANO MEDICAL SCIENCES S.R.L. CALDARELLI, Marina BERIA, Italo COLOMBO, Nicoletta PIUTTI, Claudia SALSA, Matteo TRAQUANDI, Gabriella
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| Structure |
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Download2D MOL |
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| Formula |
C21H22N6O3
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| Canonical SMILES |
CN1CCN(CC1)C2=CC=C(C=C2)OC3=NC=C4CCC5=C(ON=C5C4=N3)C(=O)N
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| InChI |
1S/C21H22N6O3/c1-26-8-10-27(11-9-26)14-3-5-15(6-4-14)29-21-23-12-13-2-7-16-18(17(13)24-21)25-30-19(16)20(22)28/h3-6,12H,2,7-11H2,1H3,(H2,22,28)
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| InChIKey |
CMFVPEXDTAEYSG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dual specificity protein kinase TTK (MPS1) | Target Info | Inhibitor | [1] |
| PRKR-like endoplasmic reticulum kinase (PERK) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Dual specificity protein kinase TTK (MPS1) | Target's Patent Info | [1] | |
| PRKR-like endoplasmic reticulum kinase (PERK) | Target's Patent Info | [1] | ||
| KEGG Pathway | Cell cycle | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| WikiPathways | Retinoblastoma (RB) in Cancer | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. | |||
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