Drug Information
Drug General Information | Top | |||
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Drug ID |
D06GDH
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Former ID |
DCL000763
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Drug Name |
DA-5018
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Synonyms |
Capsavanil; Davasaicin; Da 5018; KR-25018; Benzeneacetamide, 4-(2-aminoethoxy)-N-(3-(3,4-dimethylphenyl)propyl)-3-methoxy-, monohydrochloride; 2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[3-(3,4-dimethylphenyl)propyl]acetamide; 2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[3-(3,4-dimethylphenyl)propyl]acetamide hydrochloride
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Drug Type |
Small molecular drug
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Indication | Diabetic neuropathy [ICD-11: 8C0Z] | Discontinued in Phase 2 | [1] | |
Postherpetic neuralgia [ICD-11: 1E91.5; ICD-10: G53.0] | Discontinued in Phase 2 | [1] | ||
Company |
Dong-A
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Structure |
Download2D MOL
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Formula |
C22H31ClN2O3
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Canonical SMILES |
CC1=C(C=C(C=C1)CCCNC(=O)CC2=CC(=C(C=C2)OCCN)OC)C.Cl
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InChI |
1S/C22H30N2O3.ClH/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3;/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25);1H
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InChIKey |
OUEKLNJUMVZULZ-UHFFFAOYSA-N
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CAS Number |
CAS 174661-97-3
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Modulator | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
Reactome | TRP channels |
References | Top | |||
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REF 1 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | |||
REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
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