Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06FFZ
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| Former ID |
DIB019593
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| Drug Name |
PMID26080733C7r
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| Synonyms |
GTPL8639
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C27H28FN5O2
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| Canonical SMILES |
CCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3C=CC(=C4)C5=C(C(=CC=C5)OC)F
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| InChI |
1S/C27H28FN5O2/c1-3-32-13-15-33(16-14-32)20-10-7-18(8-11-20)27(34)29-26-22-12-9-19(17-23(22)30-31-26)21-5-4-6-24(35-2)25(21)28/h4-12,17H,3,13-16H2,1-2H3,(H2,29,30,31,34)
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| InChIKey |
ANMVTYAYYHHSTF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fibroblast growth factor receptor 1 (FGFR1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| Ras signaling pathway | ||||
| Rap1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Adherens junction | ||||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Regulation of actin cytoskeleton | ||||
| Pathways in cancer | ||||
| Proteoglycans in cancer | ||||
| Prostate cancer | ||||
| Melanoma | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| FGF signaling pathway | ||||
| Pathway Interaction Database | Glypican 1 network | |||
| Syndecan-4-mediated signaling events | ||||
| N-cadherin signaling events | ||||
| FGF signaling pathway | ||||
| WikiPathways | Regulation of Actin Cytoskeleton | |||
| Endochondral Ossification | ||||
| MAPK Signaling Pathway | ||||
| Mesodermal Commitment Pathway | ||||
| Hair Follicle Development: Induction (Part 1 of 3) | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Signaling Pathways in Glioblastoma | ||||
| Neural Crest Differentiation | ||||
| Signaling by FGFR | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold. Org Biomol Chem. 2015 Jul 28;13(28):7643-54. | |||
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