Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06DKB
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| Former ID |
DNC011027
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| Drug Name |
GNF-PF-4478
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| Synonyms |
GNF-Pf-4478; CHEMBL597857; SMR000042305; AC1LD5U9; MLS000036444; cid_661700; MolPort-002-590-307; HMS2349M09; ZINC20191037; MMV006587; STK552090; BDBM50322743; AKOS005479117; MCULE-5579816479; NCGC00019462-02; NCGC00019462-01; 8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]indol-4-amine; 8-chloro-N-[3-(morpholin-4-yl)propyl]-5H-pyrimido[5,4-b]indol-4-amine; 8-chloro-N-(3-morpholin-4-ylpropyl)-5H-pyrimido[5,4-b]indol-4-amine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H20ClN5O
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| Canonical SMILES |
C1COCCN1CCCNC2=NC=NC3=C2NC4=C3C=C(C=C4)Cl
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| InChI |
1S/C17H20ClN5O/c18-12-2-3-14-13(10-12)15-16(22-14)17(21-11-20-15)19-4-1-5-23-6-8-24-9-7-23/h2-3,10-11,22H,1,4-9H2,(H,19,20,21)
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| InChIKey |
ULJISGNQAXNPOC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Insulin-degrading enzyme (IDE) | Target Info | Inhibitor | [1] |
| Trypanosoma Cruzipain (Trypano CYSP) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Alzheimer's disease | |||
| WikiPathways | Alzheimers Disease | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | |||
| REF 2 | Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. | |||
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