Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06CZJ
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| Former ID |
DNAP001330
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| Drug Name |
Idursulfase
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| Synonyms |
Elaprase (TN)
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| Indication | Hunter syndrome [ICD-11: 5C56.31; ICD-10: E76.1] | Approved | [1], [2], [3] | |
| Infertility [ICD-11: GB04; ICD-10: N46] | Approved | [1], [2], [3] | ||
| ADReCS Drug ID | BADD_D01132 | |||
| SuperDrug ATC ID |
A16AB09
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Iduronate 2-sulfatase (IDS) | Target Info | Modulator | [1], [2] |
| BioCyc | Dermatan sulfate degradation (metazoa) | |||
| KEGG Pathway | Glycosaminoglycan degradation | |||
| Metabolic pathways | ||||
| Lysosome | ||||
| Reactome | HS-GAG degradation | |||
| CS/DS degradation | ||||
| WikiPathways | Glycosaminoglycan metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. | |||
| REF 2 | A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome). Genet Med. 2006 Aug;8(8):465-73. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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