Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06AHQ
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| Former ID |
DIB005504
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| Drug Name |
Ro-31-8830
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| Synonyms |
Ro-31-8830; 131848-98-1; 3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; 3-{8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-4-(1-methyl-1h-indol-3-yl)-1h-pyrrole-2,5-dione; Bisindolylmaleimide deriv. 18b; ACMC-20caiw; Ro 31-8830; AC1L1JKR; AC1Q6PDZ; CHEMBL95925; SCHEMBL5036866; BDBM2705; CTK0H9238; HMS3401J16; HMS3401G14; HSCI1_000347; BIM 11; Bisindolylmaleimide XI, HCl; NCGC00163696-04; NCGC00163696-01; K00206
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| Drug Type |
Small molecular drug
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Terminated | [1] | |
| Company |
Roche Holding AG
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| Structure |
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Download2D MOL |
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| Formula |
C28H28N4O2
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| Canonical SMILES |
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C
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| InChI |
1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)
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| InChIKey |
FXGHOAZJQNLNFD-UHFFFAOYSA-N
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| CAS Number |
CAS 131848-98-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein kinase C (PRKC) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001273) | |||
| REF 2 | Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor. Agents Actions. 1992 Sep;37(1-2):85-9. | |||
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