Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05ZYM
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| Former ID |
DAP000872
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| Drug Name |
N-Acetyl-D-glucosamine
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| Synonyms |
Aflexa; GlcNAc; NAcGlc; NDG; Crab Shell Chitin; Glucosamine Complex; Maxi GS; Natures Blend Glucosamine; Pharmaceutical aid; JFD00446; SB01966; GS-500; N-Acetylchitosamine; N-Acetylchondrosamine; N-Acetylgalactosamine; N-Acetylhexosamine; Glucosamine, N-acetyl; N-Acetyl-D-Allosamine; N-Acetyl-D-galactosamine; N-Acetyl-D-hexosamine; N-acetyl-D-mannosamine; N-Acetyl-D-glucosamine-Agarose; N-Acetyl-alpha-D-glucosamine; N-acetyl-alpha-D-glucosaminides; N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(2R,3R,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; 2-(Acetylamino)-2-deoxyhexopyranose; 2-ACETAMIDO-2-DEOXY-D-ALLOSE; 2-Acetamido-2-deoxy-D-glucose; 2-Acetamido-2-deoxyglucose; 2-Acetamido-D-glucose; 2-acetamido-2-deoxy-D-glucopyranose; 2-acetamido-2-deoxyhexopyranose; 6-Acetamido-6-deoxy-.alpha.-D-glucopyranose; 6-Acetamido-6-deoxy-acpha-D-glucopyranose
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| Drug Type |
Small molecular drug
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| Indication | Autoimmune diabetes [ICD-11: 5A10] | Approved | [1] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
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Download2D MOL |
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| Formula |
C8H15NO6
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| Canonical SMILES |
CC(=O)NC1C(C(C(OC1O)CO)O)O
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| InChI |
1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
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| InChIKey |
OVRNDRQMDRJTHS-RTRLPJTCSA-N
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| CAS Number |
CAS 72-87-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3440, 3140764, 10298230, 11533139, 14749116, 14773579, 24890642, 26701755, 34746915, 36883433, 49754856, 53790128, 56320705, 56322637, 56475046, 57402888, 78904968, 81059563, 81059603, 81060201, 81060576, 81061195, 81063201, 81063230, 81064621, 83120340, 85695113, 87561789, 96100315, 103910763, 104619820, 124799573, 128868544, 134338149, 135373470, 136161975, 139264390, 139272492, 144204897, 152054145, 152187909, 160677138, 160963490, 162025026, 162226631, 163072598, 163814101, 164187219, 175442678, 180101034
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| ChEBI ID |
CHEBI:506227
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Alpha-N-acetylglucosaminidase (NAGLU) | Target Info | Activator | [2], [3] |
| KEGG Pathway | Glycosaminoglycan degradation | |||
| Metabolic pathways | ||||
| Lysosome | ||||
| Reactome | HS-GAG degradation | |||
| WikiPathways | Glycosaminoglycan metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of N-Acetyl-D-glucosamine, 2008. eduDrugs. | |||
| REF 2 | Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal Fibroblast Cells. J Biomater Sci Polym Ed. 2009;20(10):1335-51. | |||
| REF 3 | Role of N-linked polymannose oligosaccharides in targeting glycoproteins for endoplasmic reticulum-associated degradation. Cell Mol Life Sci. 2004 May;61(9):1025-41. | |||
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