Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05YLL
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| Former ID |
DIB011136
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| Drug Name |
FL-386
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| Synonyms |
Benzene sulfonic acid 2-(trans-4-isobutylcyclohexyl)-2-oxoethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H26O4S
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| Canonical SMILES |
CC(C)CC1CCC(CC1)C(=O)COS(=O)(=O)C2=CC=CC=C2
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| InChI |
1S/C18H26O4S/c1-14(2)12-15-8-10-16(11-9-15)18(19)13-22-23(20,21)17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3
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| InChIKey |
RLVLLBHWAQWLKL-UHFFFAOYSA-N
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| CAS Number |
CAS 84856-18-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Modulator | [2], [3] |
| BioCyc | Pyrimidine ribonucleosides degradation | |||
| Thymine degradation | ||||
| Uracil degradation | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| beta-Alanine metabolism | ||||
| Pantothenate and CoA biosynthesis | ||||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Panther Pathway | Pyrimidine Metabolism | |||
| Pathwhiz Pathway | Beta-Alanine Metabolism | |||
| Pyrimidine Metabolism | ||||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002285) | |||
| REF 2 | Effects of FL-386 on faecal lipid excretion in humans. J Int Med Res. 1993 Sep-Oct;21(5):225-33. | |||
| REF 3 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | |||
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