Drug Information
Drug General Information | Top | |||
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Drug ID |
D05YLL
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Former ID |
DIB011136
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Drug Name |
FL-386
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Synonyms |
Benzene sulfonic acid 2-(trans-4-isobutylcyclohexyl)-2-oxoethyl ester
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Drug Type |
Small molecular drug
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Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Discontinued in Phase 2 | [1] | |
Structure |
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Download2D MOL |
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Formula |
C18H26O4S
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Canonical SMILES |
CC(C)CC1CCC(CC1)C(=O)COS(=O)(=O)C2=CC=CC=C2
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InChI |
1S/C18H26O4S/c1-14(2)12-15-8-10-16(11-9-15)18(19)13-22-23(20,21)17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3
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InChIKey |
RLVLLBHWAQWLKL-UHFFFAOYSA-N
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CAS Number |
CAS 84856-18-8
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Modulator | [2], [3] |
BioCyc | Pyrimidine ribonucleosides degradation | |||
Thymine degradation | ||||
Uracil degradation | ||||
KEGG Pathway | Pyrimidine metabolism | |||
beta-Alanine metabolism | ||||
Pantothenate and CoA biosynthesis | ||||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Panther Pathway | Pyrimidine Metabolism | |||
Pathwhiz Pathway | Beta-Alanine Metabolism | |||
Pyrimidine Metabolism | ||||
WikiPathways | Metabolism of nucleotides | |||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002285) | |||
REF 2 | Effects of FL-386 on faecal lipid excretion in humans. J Int Med Res. 1993 Sep-Oct;21(5):225-33. | |||
REF 3 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. |
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