Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D05WWJ
|
|||
Former ID |
DCL000690
|
|||
Drug Name |
ALX-5407
|
|||
Synonyms |
2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Schizophrenia [ICD-11: 6A20] | Phase 1 | [1], [2] | |
Company |
NPS Pharmaceuticals
|
|||
Structure |
Download2D MOL |
|||
Formula |
C24H24FNO3
|
|||
Canonical SMILES |
CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O
|
|||
InChI |
1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1
|
|||
InChIKey |
FDORQEIHOKEJNX-HSZRJFAPSA-N
|
|||
PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:92943
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Glycine transporter GlyT-1 (SLC6A9) | Target Info | Blocker | [2], [3] |
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | NRF2 pathway |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4618). | |||
REF 2 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. | |||
REF 3 | ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.